domingo, 21 de julio de 2024

New Topical Therapy for Moderate Psoriasis: An Open-Label, Pilot Study

New Topical Therapy for Moderate Psoriasis: An Open-Label, Pilot Study


José Miguel Ingelmo Calvo (1), José Ruiz Cobo (2), Mohamed Farouk Allam (3)*

1. Department of Plastic Surgery, Hospital HM Malaga, Malaga, Spain.

2. Distrito Sanitario Costa del Sol, SUAP Torremolinos, Malaga, Spain.

3. Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

 

International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR) 2024;14(2):31-34.

 

https://doi.org/10.51847/8b1eX1xZRO

 

Abstract

Psoriasis is a persistent, recurring condition characterized by numerous complications. Currently, there is no definitive cure for psoriasis, and treatments typically provide temporary relief of symptoms. Patent 202030824, an innovative cream for psoriasis local treatment, was issued by the Spanish Ministry of Industry, Trade, and Tourism. This product is called "Psorisbye," and it's a foamy lotion that contains clobetasol, propylene glycol, spironolactone, milk-peptide complex, and papaverine hydrochloride. We report on five cases of mild psoriasis that responded well to our recently developed foamy lotion treatment. Our pilot study is an open-label intervention study involving patients with moderate psoriasis. Initially, each patient underwent a comprehensive assessment, encompassing a thorough history-taking and clinical examination. Next, instructions were given to each patient to use our recently developed foamy lotion once a day for a week, using a total of 120 ml of the product during this time. The patients had a follow-up evaluation in the outpatient clinic following a 7-day period of local application. Every patient noted a remission of scaling lesions and claimed a significant reduction in itching sensations. The mean pre-treatment PASI of the patients was 20.28 (SD 6.1), while the mean post-treatment PASI was 1.8. Our preliminary investigation indicated promising results in the treatment of moderate psoriasis with "Psorisbye". Notwithstanding these encouraging results, a longer follow-up is necessary to assess the length of psoriasis remission and any possible adverse effects related to this novel topical medication.

 

Key Words: Psoriasis, Topical therapy, Psoriasis area severity index, Case series, Malaga.


Calvo JMI, Cobo JR, Allam MF. New Topical Therapy for Moderate Psoriasis: An Open-Label, Pilot Study. Int J Pharm Phytopharmacol Res 2024;14(2):31-4. https://doi.org/10.51847/8b1eX1xZRO


https://eijppr.com/article/new-topical-therapy-for-moderate-psoriasis-an-open-label-pilot-study-rrp5cpnekgzdr3i

sábado, 22 de junio de 2024

The effects of probiotic Lactobacillus acidophilus and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: Randomized controlled clinical trial

The effects of probiotic Lactobacillus acidophilus and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: Randomized controlled clinical trial

Samar Osama Hassan (1), Ahmed Nour El-Din Hassan (2,3), Manal Sabry Mohamed (4), Mohamed Nabil Badawy Al Ashram (4), Mina Michael Nesim (4), Mohamed Farouk Allam (1)

1. Family Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2. Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
3. Clinical Pharmacology Department, Faculty of Medicine, Galala University, Egypt.
4. Internal Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Microbes and Infectious Diseases 2024;5(3):901-910.

Doi: 10.21608/MID.2024.281579.1877

Background: Coronavirus disease 2019 (COVID-19) is a newly emerging human disease caused by a novel coronavirus, causing a global pandemic crisis. Probiotics and/or colchicine may be considered as options for treatment since they have anti-viral, anti-inflammatory, and immunomodulatory effects. Results: A total of 150 patients with mild and moderate severity of COVID-19 were enrolled in the study, 50 patients in each arm; around one third (34.7%) of the participants were aged between 29 and 39 years; one-quarter (24.7%) were aged between 18 and 28 years and 40.6% were aged 40 years and above. The mean duration of symptoms improvement was 12, 11 and 12 in the colchicine, probiotic, and control groups, respectively. Improvement of inflammatory markers over time occurred in each of the three groups, with no statistically significant difference between them. Conclusion: Probiotic Lactobacillus acidophilus and colchicine shows no significant effect on the symptoms, duration, and progression of mild and moderate cases of COVID-19.

Keywords: COVID-19, RCT, Ain Shams University, Cairo.

Hassan SO, Hassan AN, Mohamed MS, Al Ashram MNB, Nesim MM, Allam MF. The effects of probiotic Lactobacillus acidophilus and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: Randomized controlled clinical trial. Microbes and Infectious Diseases, 2024. doi: 10.21608/mid.2024.281579.1877

Web page: https://mid.journals.ekb.eg/article_352344.html

https://mid.journals.ekb.eg/article_352344_11d92885b09d83a148c09a43886771b0.pdf

 

martes, 18 de junio de 2024

Role of Melatonin in Management of COVID-19: A Systematic Review

Role of Melatonin in Management of COVID-19: A Systematic Review

Ghada Essam El-Din Amin (1,2), Salwa Mostafa Mohammad Abdel Rahman (3), Rehab Mohamed Ali Mohamed (1), Mohamed Farouk Allam (1,2)

1. Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

2. Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

3. Department of Anesthesia and Intensive Care, Faculty of Medicine, Ain Shams University, Ain Shams University, Cairo, Egypt.

 

Microbes, Infection and Chemotherapy 2024; 4: e1982.

 

DOI: 10.54034/mic.e1982

 

Abstract

Background: the COVID-19 pandemic has significantly impacted global healthcare and economic systems. The clinical manifestation of the disease varies from flu-like symptoms to severe pneumonia and, in some cases, death. Melatonin and its metabolites play a crucial role in immunomodulation and possess anti-oxidative properties, capable of directly and indirectly scavenging reactive oxygen species. Objective: the aim of the present systematic review was to assess the effectiveness of melatonin in the management of COVID-19 patients and its role in expediting the return of patients to their baseline health. Methodology: the literature review was conducted up to August 2022, resulting in the identification of 533 articles after sorting them by authors and year of publication. Following the removal of 223 duplicate articles, 310 abstracts were screened, leading to the exclusion of 281. Subsequently, 29 full-text studies were evaluated for eligibility, with 22 being excluded. Finally, seven studies met the inclusion criteria and were included for further qualitative and quantitative analyses. Results: the findings revealed a noteworthy reduction in hospital stay among patients who received melatonin compared to those who received a placebo (standardized mean difference: -0.50, Standard error: 0.15, 95% CI: -0.80, -0.20, P value: 0.001). Melatonin was associated with a significant decrease in mortality in COVID-19 patients when compared to the placebo (Pooled RR: 0.21, 95% CI: 0.08, 0.56, P value: 0.002). However, there were no significant differences between melatonin and placebo regarding the need for hospitalization, ICU admission, artificial ventilation, and the requirement for oxygen therapy. Conclusion: melatonin may decrease the mortality rate among patients with COVID-19. Melatonin may reduce the duration of hospital stay in patients with COVID-19. Melatonin had no effect on the following outcomes in COVID-19 patients: the need for hospitalization, ICU admission, artificial ventilation and the need for oxygen therapy.


Key word: coronavirus disease 2019, severe acute respiratory syndrome, Middle East respiratory syndrome.

Amin, G. E. E.- din, Abdel Rahman, S. M. M., Mohamed , R. M. A., & Allam, M. F. (2024). Role of Melatonin in Management of COVID-19: A Systematic Review. Microbes, Infection and Chemotherapy4, e1982.

https://revistas.unheval.edu.pe/index.php/mic/article/view/1982


lunes, 17 de junio de 2024

The potential therapeutic effect of vitamin D supplementation for managment of SARS-COV-2: a systematic review/meta-analysis

The potential therapeutic effect of vitamin D supplementation for managment of SARS-COV-2: a systematic review/meta-analysis

Lobna Mohamed Bahaa El-Din Mohamed (1), Mohamed Nazmy Farres (2), Ghada Essam El-Din Amin (3,4), Mohamed Farouk Allam (1,4), Rasha Samir (5) 

1. Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

2. Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

3. Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

4. Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, October 6 University, Cairo, Egypt.

5. Department of Internal Medicine, Armed Forces College of Medicine, Cairo, Egypt.

 

Microbes, Infection and Chemotherapy 2024; 4: e1964.

 

DOI: 10.54034/mic.e1964

 

Abstract

Background: vitamin D deficiency has long been associated with decreased immune function and can lead to viral infections. Studies have shown that vitamin D deficiency is associated with an increased risk of COVID-19 infection. However, it is unclear whether treatment with vitamin D can reduce the associated risk of COVID-19 infection. Objective: the current meta-analysis aimed to determine whether vitamin D supplementation had a positive or negative impact on COVID-19 patients. Materials and methods: for this systematic review and meta-analysis, we searched the following databases; CENTERAL, Medline (PubMed), Web of Science, EMBASE and Egyptian Knowledge Bank (EKB, for studies published till February 20, 2022, using key terms. Besides, reference lists of relevant studies were identified. We considered randomized trials (RCTs) and cohort studies as potentially eligible when patients were tested for SARS-CoV-2 infection and received vitamin D supplementation versus a placebo or standard-of-care control. We identified a total of 718 articles, of which 4 RCTs and 3 cohort studies which meet eligible criteria. The seven studies included in our meta-analysis involved 1238 subjects. We considered 7 outcomes to be measured in our meta-analysis which are duration of COVID-19 illness till recovery, need for O2 therapy, need for ICU admission, need for artificial ventilation, fatal prognosis, time to negative PCR and need for hospitalization. Results: vitamin D supplement decreased the period of hospital stay in SARS-CoV2 positive patients. There was no clear protective effect of vitamin D supplementation on the need for oxygen therapy. There was no reduction on need for ICU admission in SARS-CoV2 patients treated with vitamin D supplementation. There was a significant reduction on need for artificial ventilation in patients treated with vitamin D supplementation. Our meta-analysis showed that there is no reduction on fatal prognosis in patients treated with vitamin D supplementation. Only one RCT evaluated time to negative PCR; this study was conducted in India and showed that vitamin D supplementation helped to achieve SARS-CoV-2 RNA negativity in greater proportion of COVID-19 patients with vitamin D supplementation. Conclusion: administration of vitamin D after diagnosis of SARS-CoV-2 infection reduces the period of hospital stay and also reduces the need for artificial ventilation.

 

Keywords: Vitamin D Supplementation, SARS-COV-2, Management, Meta-analysis, Ain Shams University.

 

Bahaa El-Din, L. M., Farres, M. N., Amin, G. E. E.-D., Allam, M. F., & Samir, R. (2024). The potential therapeutic effect of vitamin D supplementation for management of SARS-COV-2: a systematic review/meta-analysis. Microbes, Infection and Chemotherapy, 4, e1964.

 

https://revistas.unheval.edu.pe/index.php/mic/article/view/1964

Rate of post Covid-19 symptoms: a systematic review and meta-analysis

Rate of post Covid-19 symptoms: a systematic review and meta-analysis

 

Nesma Nabil Ahmed Elgohary (1), Mohamed Nazmy Farres (2), Diaa Marzouk Abdelhamid , Salwa Mostafa Mohamed (3), Mohamed Farouk Allam (1)

 

1. Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

2. Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

3. Department of Anesthesia and Intensive Care, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

 

Microbes, Infection and Chemotherapy 2024; 4: e198.

 

DOI: 10.54034/mic.e1981

 

Abstract

 

Background. Covid-19 pandemic has led to global pandemic and substantial health, economic and social impact. The causative agent is coronavirus-2 (SARS-CoV-2) which belongs to the coronavirus family. The clinical picture of the infection ranges from a flulike symptoms to severe pneumonia and mortality. Till January 2022, the cumulative number of cases exceeded 600 million worldwide with mortality rate of more than 6 million. Objective: to identify rate of total and individual presentations of post COVID-19 conditions. Methodology: the literature was reviewed till 1st July 2022, in six databases, we identified 5486 articles; after removal of duplicates and screening for eligible studies according to inclusion criteria, 17 studies were included for further qualitative and quantitative analysis. Results: the results showed high rate of post COVID-19 condition among patients. With prevalence rate of 5 to 10%, fatigue was the most reported symptom with prevalence of 34% among patients (RE: 0.33%, 95%CI: 0.32-0.35). The second highest common symptom was breathlessness with prevalence of 31% (RE: 0.31, 95%CI: 0.20-0.43). Mental health symptoms including anxiety and depression were also distinctly frequent. We also reported on different neurocognitive symptoms including attention and memory problems with rate of 16% (RE: 0.16, 95%CI: 0.11-0.22) and 19% (RE: 0.19, 95%CI: 0.14-0.26) respectively. Conclusion: it is apparent that a significant percentage of individuals with COVID-19 (45%) continue to grapple with a variety of persistent symptoms. Among these, fatigue and dyspnea emerge as highly prevalent issues consistently reported across various groups of patients. However, it is evident that a considerable portion of patients also contend with a diverse array of other lingering symptoms, displaying variability both in number and severity.

 

Key word: Sars-CoV-2, Covid-19, post Covid-19, prevalence, dyspnea, fatigue, mental health.

 

Elgohary NNA, Farres MN, Abdelhamid DM, Mohamed SM, Allam MF. Rate of post Covid-19 symptoms: a systematic review and metaanalysis. Microbes Infect Chemother. 2024; 4: e1981.

https://revistas.unheval.edu.pe/index.php/mic/article/view/1981