The
association between coffee consumption and bladder cancer in the bladder cancer
epidemiology and nutritional determinants (BLEND) international pooled study
Yu EY(1)(2), Wesselius
A(3), van Osch F(3)(4), Stern MC(5), Jiang X(5), Kellen E(6), Lu CM(7),
Pohlabeln H(8), Steineck G(9), Marshall J(10), Allam MF(11), La Vecchia C(12), Johnson
KC(13), Benhamou S(14), Zhang ZF(15), Bosetti C(16), Taylor JA(17), Zeegers
MP(3)(18).
Author information:
(1)NUTRIM School for
Nutrition and Translational Research in Metabolism, University of Maastricht,
Universiteitssingel 40 (Room C5.564), 6229 ER, Maastricht, The Netherlands.
evan.yu@maastrichtuniversity.nl.
(2)CAPHRI School for
Public Health and Primary Care, University of Maastricht, Maastricht, The
Netherlands. evan.yu@maastrichtuniversity.nl.
(3)NUTRIM School for
Nutrition and Translational Research in Metabolism, University of Maastricht,
Universiteitssingel 40 (Room C5.564), 6229 ER, Maastricht, The Netherlands.
(4)Institute of Cancer
and Genomic Sciences, University of Birmingham, Birmingham, UK.
(5)Department of
Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
(6)Leuven University
Centre for Cancer Prevention (LUCK), Louvain, Belgium.
(7)Department of
Urology, Buddhist Dalin Tzu Chi General Hospital, Dalin Township, Chiayi
County, Taiwan.
(8)Leibniz Institute
for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
(9)Clinical Cancer
Epidemiology, Department of Oncology, Clinical Sciences, Sahlgrenska Academy,
University of Gothenburg, Gothenburg, Sweden.
(10)Department of
Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
(11)Department of
Medical and Surgical Specialties, Radiological Sciences and Public Health,
Section of Public Health and Human Sciences, University of Brescia, Brescia,
Italy.
(12)Department of
Clinical Medicine and Community Health, University of Milan, Milan, Italy.
(13)Department of
Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada.
(14)INSERM U946,
Variabilite Genetique et Maladies Humaines, Fondation Jean Dausset/CEPH, Paris,
France.
(15)Departments of
Epidemiology, UCLA Center for Environmental Genomics, Fielding School of Public
Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
(16)Laboratory of
Oncology, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS,
Milan, Italy.
(17)Epidemiology Branch
and Epigenetic and Stem Cell Biology Laboratory, National Institute of
Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
(18)CAPHRI School for
Public Health and Primary Care, University of Maastricht, Maastricht, The
Netherlands.
Cancer
Causes Control. 2019 May 30. [Epub ahead of print] PubMed PMID:
31147895.
doi:
10.1007/s10552-019-01191-1.
BACKGROUND:
Inconsistent results for coffee consumption and bladder cancer (BC) risk have
been shown in epidemiological studies. This research aims to increase the understanding
of the association between coffee consumption and BC risk by bringing together
worldwide case-control studies on this topic.
METHODS: Data were
collected from 13 case-control comprising of 5,911 cases and 16,172 controls.
Pooled multivariate odds ratios (ORs), with corresponding 95% confidence
intervals (CIs), were obtained using multilevel logistic regression models. Furthermore,
linear dose-response relationships were examined using fractional polynomial
models.
RESULTS: No association
of BC risk was observed with coffee consumption among smokers. However, after
adjustment for age, gender, and smoking, the risk was significantly increased
for never smokers (ever vs. never coffee consumers: ORmodel2 1.30, 95% CI
1.06-1.59; heavy (> 4 cups/day) coffee consumers vs. never coffee consumers:
ORmodel2 1.52, 95% CI 1.18-1.97, p trend = 0.23). In addition, dose-response
analyses, in both the overall population and among never smokers, also showed a
significant increased BC risk for coffee consumption of more than four cups per
day. Among smokers, a significant increased BC risk was shown only after
consumption of more than six cups per day.
CONCLUSION: This
research suggests that positive associations between coffee consumption and BC
among never smokers but not smokers.
https://link.springer.com/article/10.1007%2Fs10552-019-01191-1
