Role of Probiotics for Treatment of Psoriasis?
Amany
Abdelrahman Kamel Mahmoud (1), Ghada Essam El-Din Amin (1), Marwa Abd El-Rahim
Abdallah (2), Marwa Yassin Soltan (2), Mohamed Farouk Allam (1,*)
1.
Department of Family Medicine, Faculty of Medicine, Ain Shams University,
Cairo, Egypt
2.
Department of Dermatology, Venerology and Andrology, Faculty of Medicine, Ain
Shams University, Cairo, Egypt
*Correspondence:
Mohamed Farouk Allam (farouk.allam@med.asu.edu.eg)
DOI:
10.31586/wjmm.2022.413
Abstract:
Psoriasis
is a multi-systemic chronic autoimmune inflammatory disorder affecting 125
million people worldwide. The most common type of psoriasis is plaque psoriasis
affecting up to 90% of the patients and is characterized by well-demarcated,
symmetric, and erythematous plaques with overlying silvery scales that may be
painful or itchy. Psoriasis may also affect the joints; increase the risk of
developing metabolic syndrome, diabetes, Crohn’s disease, ulcerative colitis,
uveitis, certain cancers and an increase in the risk of cardiovascular
diseases. Both the skin and the gut microbiome can modulate the development and
progression of psoriasis. A connection between the microbiome and immunological
mechanisms are antimicrobial peptides, which regulate the microbiome at interfaces
and, as antigens, can trigger psoriasis. Few studies were conducted to
demonstrate the effect of probiotics on different diseases, as they are living
microorganisms that confer a health benefit when administrated in adequate
amounts. The effects of administering probiotics include the stabilization of
the gut bacterial community and the restoration of “signature” of bacterial
microbiota, which is a result of lowering the pH, producing bacteriocins,
altering microRNA (miRNAs), competing with pathogens for certain nutrients and
improving the gut barrier function. Probiotics counter weight aggressive
commensals in the body and reinforce the barrier function of the epithelium
while also contributing to the regulation of innate and adaptive immune responses
of the host under healthy or pathogenic conditions. Several clinical trials
were conducted based on those findings to examine the role of probiotics in
psoriasis, but till now there is no evidence of their efficacy.
Keywords: Psoriasis, Plaques, Probiotics, Microbiota, Quality of Life, Review.
World
Journal of Medical Microbiology, 2022, 1, 413.
https://www.scipublications.com/journal/index.php/wjmm/article/view/413
