Sociodemographic and Clinical Characteristics of Diabetic Patients with Peripheral Arterial Disease In 2 Centers
Emad Ahmed Hussein (1), Hala
Ahmed Talkhan (2), Mohamed Farouk Allam (3)*, Amr Nabil Kamel (1), Marwa Rushdy
Elnajjar (2), Mohamed Mahmoud Zaki (1)
1. Department of Vascular Surgery,
Ain Shams University, Cairo, Egypt.
2. Department of Clinical Pathology,
Ain Shams University, Cairo, Egypt.
3. Department of Family Medicine
Faculty of Medicine, Ain Shams University 11566 Abbasia, Cairo, Egypt.
DOI: 10.21608/asmj.2025.360251.1391
Abstract
Background:
Comparing revascularization outcomes between the UK and Egypt helps identify
clinical differences, outcome predictors, and healthcare disparities, guiding
context-specific management for diabetic patients with peripheral arterial
disease (PAD). Aim: This study aimed to assess the clinical characteristics,
outcomes, and predictors among patients undergoing revascularization in two
tertiary centres. Methods: From March 2019 to December 2021, diabetic PAD
patients undergoing revascularization were recruited from Royal Free Hospital
(RFH), London, UK, and Ain Shams University Hospitals (ASUHs), Cairo, Egypt.
Due to the COVID-19 pandemic, only 43 patients were included—17 from RFH and 26
from ASUHs—and followed for 3 months post-procedure. Sociodemographic data,
medical history, and outcomes were collected. Egyptian patients also underwent
pre- and postoperative testing for vascular inflammatory biomarkers: hsCRP,
D-dimer, fibrinogen, Cystatin C, and LDL. Results: RFH patients were
significantly older than ASUHs patients (70.1 vs. 60.5 years, p=0.004). Most
were male (82.4% RFH, 84.6% ASUHs). ASUHs patients had higher rates of smoking
(65.4% vs. 35.3%), obesity (50% vs. 11.8%, p=0.01), and hypercholesterolemia
(76.9% vs. 17.6%, p=0.000). RFH patients had more renal insufficiency (58.8%
vs. 3.8%, p=0.000) and foot ulcers (82.4% vs. 39.5%, p=0.006). Despite
differences, favourable outcomes were similar (82.4% RFH vs. 88.5% ASUHs).
Among ASUHs patients, postoperative reductions in LDL (p=0.03) and Cystatin C
(p=0.13) were associated with better outcomes. Conclusion: ASUHs patients were
younger and had different risk profiles, but clinical outcomes were comparable.
Biomarker changes may help predict post-revascularization recovery.
Keywords: Diabetes mellitus, endovascular treatment, hypertension, hypercholesterolemia,
obesity, peripheral arterial disease, surgical revascularization, smoking, Royal
Free University Hospitals, Ain Shams University Hospitals, Egypt, UK.
