Role of Probiotics and Colchicine in COVID-19 Management?

Role of Probiotics and Colchicine in COVID-19 Management?

Samar Osama Ahmed Hassan (1), Ahmed Nour El-Din Hassan (2), Manal Sabry Mohamed (3), Mina Michael Nesim (3), Mohamed Nabil Badawy Al Ashram (3), Mohamed Farouk Allam (1,4)

 

(1) Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

(2) Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

(3) Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

(4) Department of Community Medicine, Faculty of Medicine, October 6 University, Cairo, Egypt

 

Universal Journal of Gastroenterology and Hepatology 2023;1(1):14–16.

 

DOI: 10.31586/ujgh.2023.772

 

Abstract

 

Background: Coronavirus disease 2019 (COVID-19) is a newly emerging human disease caused by a novel coronavirus, causing a global pandemic crisis. Probiotics and/or colchicine may be considered as options for treatment since they have anti-viral, anti-inflammatory, and immunomodulatory effects. The aim of the current review was to assess the effectiveness of probiotic supplements and colchicine on symptoms, duration, and progression of mild and moderate cases of COVID-19 infection. Review: A randomized, double-blind, placebo-controlled trial in the United States with 182 participants who were randomly assigned to receive daily oral probiotic (Lactobacillus rhamnosus) LGG or placebo for 28 days. The study indicated that LGG is well-tolerated and is associated with a delay in the onset of COVID-19 infection, a reduction in the incidence of symptoms, and alterations in the structure of the gut microbiome when administered as post-exposure prophylaxis within seven days of exposure. Colchicine may lessen mortality and the need for mechanical ventilation in mild-to-moderate COVID-19 patients, according to a systematic review and meta-analysis. Conclusion: Probiotics and/or colchicine may be viable treatment options for COVID-19 patients. To examine the efficacy of probiotics and colchicine in the treatment of COVID-19, it is necessary to conduct additional clinical trials and provide clinicians with evidence, as there are currently insufficient studies to support this conclusion.

 

Keywords: Probiotics, Colchicine, COVID-19, Management, Clinical trials, Review.

 

Universal Journal of Gastroenterology and Hepatology 2023;1(1):14–16.

 

https://www.scipublications.com/journal/index.php/ujgh/article/view/772