International pooled study on diet and bladder cancer

International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics.

Arch Public Health. 2016 Jul 6;74:30. doi: 10.1186/s13690-016-0140-1. eCollection

2016.

Goossens ME(1), Isa F(2), Brinkman M(3), Mak D(2), Reulen R(2), Wesselius A(4),

Benhamou S(5), Bosetti C(6), Bueno-de-Mesquita B(7), Carta A(8), Allam MF(9),

Golka K(10), Grant EJ(11), Jiang X(12), Johnson KC(13), Karagas MR(14), Kellen E(15), La Vecchia C(16), Lu CM(17), Marshall J(18), Moysich K(18), Pohlabeln H(19), Porru S(8), Steineck G(20), Stern MC(12), Tang L(18), Taylor JA(21), van

den Brandt P(22), Villeneuve PJ(23), Wakai K(24), Weiderpass E(25), White E(26),

Wolk A(27), Zhang ZF(28), Buntinx F(29), Zeegers MP(30).

Author information:

(1)Department of General Practice, Katholieke Universiteit Leuven, ACHG-KU

Leuven, Kapucijnenvoer 33, Blok J, bus 7001, 3000 Leuven, Belgium. (2)Department of Public Health, Epidemiology and Biostatistics, University of Birmingham,Birmingham, UK. (3)The Cancer Council Victoria, Melbourne, Australia. (4)NUTRIM School for Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, The Netherlands. (5)INSERM U946, Variabilite Genetique et Maladies Humaines, Fondation Jean Dausset / CEPH, Paris, France. (6)Laboratory of General Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. (7)Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands ; Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands ; Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK ; Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. (8)Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Public Health and Human Sciences, University of Brescia, Brescia, Italy. (9)Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain. (10)Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, Germany. (11)Department of Epidemiology Radiation Effects Research Foundation, Hiroshima, Japan. (12)Department of Preventive Medicine, University of Southern California, Los Angeles, CA USA. (13)Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON Canada. (14)Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH USA. (15)Leuven University Centre for Cancer Prevention (LUCK), Leuven, Belgium. (16)Department of Clinical Medicine and Community Health, University of Milan, Milan, Italy. (17)Department of Urology, Buddhist Dalin Tzu Chi General Hospital, Dalin Township, 62247 Chiayi County Taiwan. (18)Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA. (19)Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. (20)Department of Oncology and Pathology, Division of Clinical Cancer Epidemiology, Karolinska Hospital, Stockholm, Sweden. (21)Epidemiology Branch, and Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC USA. (22)Department of Epidemiology, Schools for Oncology and Developmental

Biology and Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands. (23)Population Studies Division Health Canada, Ottawa, ON Canada. (24)Department of Preventive medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. (25)Department of Medical Epidemiology and Biostatistics, Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden ; Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway ; Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland ; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. (26)Fred Hutchinson Cancer Research Center, Seattle, WA USA. (27)Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (28)Departments of Epidemiology, UCLA Center for Environmental Genomics, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA USA. (29)Department of General Practice, Katholieke Universiteit Leuven, ACHG-KU Leuven, Kapucijnenvoer 33, Blok J, bus 7001, 3000 Leuven, Belgium ; CAPHRI School for Public Health and Primary Care, University of Maastricht, Maastricht, The Netherlands. (30)NUTRIM School for Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, The Netherlands ; CAPHRI School for Public Health and Primary Care, University of Maastricht, Maastricht, The Netherlands ; School of Cancer Sciences, University of Birmingham, Birmingham, UK.

BACKGROUND: In 2012, more than 400,000 urinary bladder cancer cases occurred worldwide, making it the 7(th) most common type of cancer. Although many previous studies focused on the relationship between diet and bladder cancer, the evidence related to specific food items or nutrients that could be involved in the development of bladder cancer remains inconclusive. Dietary components can either be, or be activated into, potential carcinogens through metabolism, or act to prevent carcinogen damage.

METHODS/DESIGN: The BLadder cancer, Epidemiology and Nutritional Determinants (BLEND) study was set up with the purpose of collecting individual patient data from observational studies on diet and bladder cancer. In total, data from 11,261 bladder cancer cases and 675,532 non-cases from 18 case-control and 6 cohort studies from all over the world were included with the aim to investigate the association between individual food items, nutrients and dietary patterns and risk of developing bladder cancer.

DISCUSSION: The substantial number of cases included in this study will enable us to provide evidence with large statistical power, for dietary recommendations on the prevention of bladder cancer.

DOI: 10.1186/s13690-016-0140-1

PMCID: PMC4933992

PMID: 27386115  [PubMed]

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